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May 14, 2020

Coronavirus | Test Kit: How do coronavirus home antibody tests work, and how do I get one?

9-12 minutes - Source: The Telegraph



A coronavirus antibody test kit has been approved by Public Health England, The Telegraph has learned, in a breakthrough that could be key to easing the UK's lockdown restrictions.

What is an antibody test?

An antibody test can detect if a person has had coronavirus before and has since recovered. The test, carried out by a device that pricks your finger for blood, works this out by testing your blood for coronavirus antibodies to see if they have already beaten the virus and gained some immunity to it.
The coronavirus swab test that the Government currently uses can only tell whether a person has the virus, not if they have had it and recovered. These swab tests also take much longer to get a result.
The antibody test is also known as a "serological test".
The Telegraph understands that the Department of Health is in negotiations with Swiss healthcare company Roche to buy millions of its coronavirus antibody test kits.
The accuracy of the test was given approval by experts at PHE’s Porton Down facility. Then, on May 13, Roche said it stood ready to provide hundreds of thousands of laboratory-based tests to the NHS each week.
The Elecsys laboratory-based test requires a blood sample to be taken by a health professional. Blood serums are obtained, to which reagents are added, and then examined in machines known as cobas e analysers, already widely installed in NHS labs across the country.
The development of an accurate antibody test is seen as key to helping Britain get back to work.
Scientists believe people who produce antibodies after having coronavirus may develop immunity to catching the virus again, making them safe to return to work.
The Government had previously hoped to roll out millions of antibody tests, but supplies from China failed to pass sensitivity and specificity tests.
Ministers will attempt to recoup taxpayers' money spent on the fingerprick tests after an Oxford University trial found they returned inaccurate results.
That failure was a significant setback because it had been hoped the antibody tests would show who had already built up immunity, therefore offering a swifter route out of lockdown.
In April, however, Professor Karol Sikora, a private oncologist and Dean of Medicine at the University of Buckingham, validated a test kit using samples from staff at his clinics, which were then verified by a private lab.
Around six per cent of staff were found to have had the virus but, crucially, under-40s who had tested positive came back negative, suggesting the test may not be useful for the wider population.
Siemens Healthineers, a German diagnostics and medical imaging firm, also announced on April 23 that it was producing an antibody blood test to identify past coronavirus infections.
The blood tests were expected to be available to large labs by late May, the company said, adding that it would be able to provide more than 25 million tests per month from June thanks to an upgrade to its manufacturing site in Massachusetts.
Another antibody test being pioneered by Oxford University could be available by the end of May, according to Professor John Newton, the UK's national testing co-ordinator.

What is an antigen test?

An antigen test detects the presence (or absence) of an antigen, not antibodies. An antigen is a structure within a virus that triggers the immune system's response to fight off the infection. It can be detected in blood before antibodies are made.
An antigen test is effective because it can take a few days for the immune system to build enough antibodies to be detected in a test, however, antigens can be detected almost immediately after infection. So, in theory, the test can tell much sooner whether someone has the virus.
Antigen tests are used to diagnose HIV, malaria and flu.

Will NHS staff be tested?

The test will enable NHS staff to know if they have been infected with – and have recovered from  the virus so they can return to work.

Who can get a coronavirus home test?

Geoff Twist, the managing director of Roche Diagnostics UK and Ireland, said the firm was working with the Government and the NHS to enable the company's test to be rolled out across the UK as soon as possible.
In theory, anyone would be able to buy other tests from Amazon or Boots. Last month, the Government ordered 3.5 million fingerprick tests, mainly from Chinese manufacturers, and later placed provisional orders for 17.5 million tests from nine firms including some based in the UK.
None of the tests were found by Oxford to be reliable enough for mass use. It could now be months before an effective coronavirus testing kit, that can be used at home, comes on the market.
But, earlier this month, some companies were still selling the antibody tests online to individuals who are desperate to find out if they have acquired immunity from the coronavirus.
On April 26, the Government was forced to deny claims it had ordered up to 50 million home testing kits.
Department of Health sources dismissed a report that 50 million antibody tests had been ordered by ministers at a cost of as little as £10 each.

Can I get a coronavirus test?

Public Health England had said that a small number of tests would be tested in a laboratory before being distributed via Amazon and sold in Boots. Had the tests passed the laboratory testing, they would then have been available to everyone.

How much would the test cost?

The Government has not yet released any official information about the cost of a test  though it would clearly be in the public interest for them to be affordable to everyone. Finger-prick tests by SureScreen, a British company, cost £6.

Who makes the coronavirus test?

The Telegraph understands that the Department of Health is in negotiations with the Swiss healthcare company Roche to buy millions of the company's kits.
Mologic, a Bedfordshire company that produces pregnancy tests, was granted £1 million by the Government to develop the coronavirus test.
SureScreen, a Derby firm, has created a finger-prick test which they say takes 10 minutes to return a result and is 98 per cent accurate. The tests are reportedly being used by private companies in a number of European countries.

Why are these tests important?

A widely available test that produces results so quickly would drastically change the UK's strategy for dealing with the virus and would change our daily lives.
In the NHS, staff would be able to return to work sooner if they know whether they have already had the virus.
People who have already had the virus and are immune would, in theory, be able to return to work and go back to their normal lives.
The impact of these tests on the economy and on public health could be enormous. See how the tests work below.

Do they use these tests in other countries?

The UK is not the only country ordering the tests.
Professor Sharon Peacock, the director of the national infection service at Public Health England, said: “Tests are being ordered across Europe and elsewhere and purchased in South-East Asia. This is widespread practice. We are not alone in doing this."
While some countries, such as South Korea and Germany, have successfully tested far more people than in other countries, these tests are in most cases the much slower swab tests.

Hundreds of thousands to be tested each day by NHS

The NHS could start testing hundreds of thousands of people per day for Covid-19 within a matter of weeks, NHS England's medical director has said.
Here is the current testing ratio:
Professor Stephen Powis told LBC, the phone-in and talk radio station, that testing is being expanded and there would be more widespread testing of NHS workers.
"We want to get hundreds of thousands of tests ramped up in the next few weeks per day," he said.
The Government is coming under intense pressure to increase testing, particularly for frontline NHS staff so those who are negative can get back to work.
Asked to clarify whether he really meant hundreds of thousands of tests per day, Professor Powis said: "That's what we are aiming for. That is what we want to ramp up to, but remember this is a new virus and we're starting from scratch.
"The kits which are required to do this testing are being manufactured as we speak. We are getting those into the country, we are ramping it up.
"I am talking of hundreds of thousands of tests.
"All of this is ramping up and increasing as we speak but, yes, you heard me correctly, we need to get to hundreds of thousands of tests a day, and we will do that over the course of the next few weeks and we will be making tests available to NHS staff within the next few days."
Figures from the Department of Health and Social Care said Public Health England (PHE) and the NHS were expecting to be carrying out up to 25,000 tests per day.
Capacity was then expected to continue to be ramped up towards 200,000 tests per day, according to the Prime Minister.
Health Secretary Matt Hancock announced that a testing facility had opened in Milton Keynes.
You can read more on the UK government's plan for testing here.

How many people are being tested for coronavirus?

The Government has met its target to conduct at least 100,000 coronavirus tests a day, Matt Hancock announced, hailing an “incredible achievement”.
The Health Secretary said 122,347 tests for Covid-19 were achieved on the final day of April.
However, the announcement swiftly attracted controversy as it emerged the tally includes swab kits sent to private homes and satellite testing sites not yet delivered to a laboratory for a result.

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