Mainland Chinese shares declined on the day, with the Shanghai composite slipping 1.20% to 3,086.40 and the Shenzhen component declining about 1.28% to 9,780.82. The Shenzhen composite also declined 1.33% to 1,665.80.
Meanwhile, Hong Kong's Hang Seng index shed about 0.1% in its final hour of trading.
In Japan, the Nikkei 225 declined 0.22% to close at 22,258.73 as shares of index heavyweights Softbank Group and Fanuc declined. The Topix also slipped 0.15% to finish its trading day at 1,617.93. Shares of Nintendo fell 1.32% after the company announced what one analyst described as "ultra-conservative guidance " for the current fiscal year.
Over in South Korea, the Kospi declined 0.51% to close at 2,179.31.
Australia bucked the overall downward trend as the ASX 200 rose marginally to close at 6,385.60.
"Share markets — globally & in Australia — have run hard and fast from their December lows and are vulnerable to a short-term pullback," Shane Oliver, head of investment strategy and chief economist at AMP Capital, wrote in a note.
But he added that things should improve by the end of this year. "Valuations are okay, global growth is expected to improve into the second half of the year, monetary and fiscal policy has become more supportive of markets and the trade war threat is receding all of which should support decent gains for share markets through 2019 as a whole."
Asia-Pacific Market Indexes Chart
The moves came as the earnings season stateside continues to roll on.
More than 170 S&P 500 companies have reported quarterly results so far, according to FactSet. Of those companies, 78% have posted better-than-expected earnings.
The U.S. dollar index, which tracks the greenback against a basket of its peers, was at 98.102 after touching lows around 98.0 yesterday. The Australian dollar changed hands at $0.7022 following an earlier low of $0.7005.
The Japanese yen traded at 111.62 against the dollar after strengthening from lows around the 112.2 handle in the previous session.
"Trading in JPY has been more influenced by the long Golden Week holiday that begins next week. The yen is stronger ahead of that as traders cut short positions ahead of the holiday," David de Garis, a director and senior economist at National Australia Bank, wrote in a morning note.
Japan is set to begin a 10-day holiday from April 27 to May 6 to celebrate the enthronement of the country's Crown Prince Naruhito.
— CNBC's Fred Imbert contributed to this report.