Investigations were triggered after the European Commission received dozens of complaints from U.S. and European competitors who claimed that the company abused its search market dominance to give its Google Shopping service an advantage over other retailers and create a monopoly over consumers.
Though the company was charged with distorting internet results by the EU competition authority in April 2015 it has not before faced fines for an abuse of this nature and marks a landmark for the way technology companies are regulated.
Shares of Google-parent Alphabet traded about 1 percent lower in the premarket.
Dow and S&P futures, meanwhile, pointed to a flat to slightly lower open as investors awaited data and key remarks from leading Federal Reserve members including Chair Janet Yellen.
A whole host of officials from the leading U.S. central bank are set to speak on Tuesday, with investors keeping an eye out for any hints as to how the U.S. economy is performing.
Fed Chair Janet Yellen will also be in the British capital, where she is set to have a conversation about global economic issues with Lord (Nicholas) Stern, the British Academy president.
Meanwhile, Minneapolis Fed President Neel Kashkari will be at a town hall forum in Michigan.
On Tuesday, San Francisco Fed President John Williams told an audience at Macquarie University in Sydney that advanced economies would find themselves stuck with slow growth over the long-term, unless fiscal authorities do something pivotal to turn things around; Reuters reported.
Stepping aside from central bank news, a slew of economic releases should come out on Tuesday including the S&P /Case-Shiller Home Price Index due out at 9.00 a.m. ET.
Consumer confidence and the Richmond Fed Manufacturing Index are also slated to be released, both out at 10 a.m. ET.
In earnings, Darden Restaurants, FactSet, IHS Markit and KB Home are due to come out.
In Europe, bourses were trading in the red during morning trade, while Asia-Pacific markets finished trade mixed to higher. In the previous session, U.S. equities finished mixed.
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—CNBC's Anita Balakrishnan and Karen Gilchrist contributed to this report.